Felty syndrome (FS), also known as ”super rheumatoid” disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and. Best Pract Res Clin Rheumatol. Oct;18(5) Felty’s syndrome. Balint GP(1), Balint PV. Author information: (1)Fourth General Rheumatology. 3 Sep Felty’s Syndrome. Aka: Felty’s Syndrome, Felty Syndrome Syndrome de Felty. Italian, Sindrome di Felty. Portuguese, Síndrome de Felty.

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Felty’s syndrome is also characterized by an abnormally enlarged spleen splenomegaly and abnormally low levels of certain white blood cells neutropenia. The knee, wrist, ankle, metacarpophalangeal and proximal interphalangeal joints are most sindrkme involved. RA in patients with Felty’s syndrome is chronic after yearsand presents with increased severity along with extra articular manifestations.

Spontaneous remission of sindrime syndrome also occurs. The increased need for production assistance of white blood cells to affected areas causes hyperfunction of the spleen. This comprises several disease-modifying anti-rheumatic drugs including sulfasalazine, hydroxychloroquine and methotrexate.

Felty’s syndrome.

Search Bing for all related images. African Americans have a low incidence of this antigen.

A palpable spleen is not always a clinical significance, therefore CT scanMRIor ultrasound can be administered in order to help diagnose the condition. The spleen is a lymphatic organ, which means it is largely involved in the flty system and immune responses.

Felty’s syndrome. – PubMed – NCBI

From Wikipedia, the free encyclopedia. Clinically it is characterized by severe joint destruction contrasting with moderate or absent joint inflammation and severe extra-articular disease, including a high frequency of rheumatoid nodules, lymphadenopathy, hepatopathy, vasculitis, leg ulcers, skin pigmentation etc. Most reports on treatment regimens involve small numbers of patients. Only comments written in English can be processed.


Neutrophils are the most abundant cells among white blood cells and play an important role in the immune system by destroying bacteria via phagocytosis. Add to My Bibliography. Microscopic analysis of spleen biopsies reveals enlargement of the germinal center in follicles, and infiltration of neutrophils and macrophages. Early presentation is commonly seen in the joints of hands and of the feet. As a result of neutropenia, affected individuals are increasingly susceptible to certain infections.

Heberden’s node Bouchard’s nodes. Rheumatology – RA Pages. Related Bing Images Extra: National Center for Biotechnology InformationU. This condition as a whole is difficult to diagnose due to its complexity given a combination of disorders. The documents contained in this web site are presented for information purposes only.

The loss and destruction of neutrophils leading to neutropenia is therefore, inflammation-driven due to the body’s need for the immune response. This syndrome is mostly present in people having extra articular manifestations of rheumatoid arthritis. Generate a file for use with external citation management software. Diagnosis of FS includes physical examination as well as complete blood count revealing leucopenia, neutropenia, and thrombocytopenia and high serum titers of rheumatoid factor antibodies, antinuclear antibodies, antihistone antibodies and HLA-DR4 positivity.

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Splenomegaly is a condition of the spleen causing it to be enlarged. It is a deforming disease that causes many complications for the individual.

In some affected individuals, Felty’s syndrome may develop during a period when the symptoms and physical findings associated with rheumatoid arthritis have subsided or are not present; in this case, Felty’s syndrome may remain undiagnosed.

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Immunosuppressive therapy for RA often improves granulocytopenia and splenomegaly; this finding reflects the fact that Felty’s syndrome is an immune-mediated disease. Bleeding pain Osteophyte villonodular synovitis Pigmented villonodular synovitis stiffness.

Severe joint destruction may be observed radiologically. By using this site, you agree to the Terms of Use and Privacy Policy.

When the spleen becomes enlarged, it is a strong sign of infection somewhere in the body, and can be caused by inflammatory conditions such as rheumatoid arthritis. The damage to the once healthy tissue causes inflammation and ultimately fluid build-up in the joint.

The condition was named after its founder Augustus Roi Felty, after the doctor reportedly saw 5 patients in with a combination of conditions never before documented.

Please review our privacy policy. In Fely syndrome, chronic activation of neutrophils progresses to neutropenia and unabated infections. Health care resources for this disease Expert centres 61 Diagnostic tests 0 Patient organisations 10 Orphan drug s 0. Prognosis FS has a poor prognosis and recurrent infections may lead to increased mortality.

Felty’s syndrome

Sindromme chemicals draw neutrophils to the area where they congregate and fight infection. Patients are at an increased risk of infection because of the low white cell counts. Felty’s SyndromeFelty Syndrome. Best Pract Res Clin Rheumatol. The condition is more common in those aged 50—70 years, specifically more prevalent in females than males, and more so in Caucasians than those of African descent.